Jeffrey S. Bostwick

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

Pancras C. Wong, Dietmar Seiffert, J. Eileen Bird et al. · Science Translational Medicine · 2017 · 144 citations

Immunology, Pharmacotherapy, Platelet Aggregation +21

Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats

William A. Schumacher, Steven E. Seiler, Thomas E. Steinbacher et al. · European Journal of Pharmacology · 2007 · 86 citations

Inflammation, Thrombosis, Thrombopoiesis +10

Conformationally Constrained <i>ortho-</i>Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y₁ Antagonist

Jennifer X. Qiao, Tammy C. Wang, Réjean Ruel et al. · Journal of Medicinal Chemistry · 2013 · 69 citations · Full text

Thrombosis, Medicinal Chemistry, Biochemistry +13

Discovery of 2-(Phenoxypyridine)-3-phenylureas as Small Molecule P2Y₁ Antagonists

Hannguang J. Chao, Huji Turdi, Timothy F. Herpin et al. · Journal of Medicinal Chemistry · 2013 · 58 citations · Full text

Adp-mediated Platelet Aggregation, Pharmacotherapy, Chemical Biology +20

Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice

J. Eileen Bird, Patricia L. Smith, Jeffrey S. Bostwick et al. · Thrombosis Research · 2011 · 39 citations

Inflammation, Thrombosis, Blood Platelet +9