Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines

D D Ross, Weidong Yang, Lynne V. Abruzzo, +7

JNCI Journal of the National Cancer Institute

Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.

E Schneider, Julie K. Horton, Masayuki Nakagawa, +1

PubMed

Breast OncologyEtoposide ResistanceCancer BiologyTumor BiologyDrug Resistance +14

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

E Schneider, KH Cowan, Hasan Bader, +4

Blood

Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells

José A. Sánchez‐Alcázar, Jeffrey G. Ault, Alexey Khodjakov, +1

Cell Death and Differentiation

Mitochondrial HyperpolarizationBiochemistryMitochondrial FunctionNatural SciencesPhysiology +12

Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway

Farzaneh Pirnia, E Schneider, Daniel Betticher, +1

Cell Death and Differentiation

InflammationSignal TransductionMitomycin CApoptosisImmunology +7

Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.

Masayuki Nakagawa, E Schneider, Katharine H. Dixon, +4

PubMed

Tumor BiologyBreast OncologyOncologySerial PassageMedicine +11

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.

K H Cowan, Jeffrey A. Moscow, Hui Huang, +22

PubMed

Cell TherapyBreast OncologyImmunologyTumor BiologyPaclitaxel Chemotherapy +16

Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.

Erin L. Volk, Kyle H. Rohde, M. Rhee, +4

PubMed

Methotrexate Cross-resistanceBreast OncologyMtx ResistantTumor BiologyDrug Resistance +14

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

Markus Borner, Charles E. Myers, Oliver Sartor, +4

PubMed

ApoptosisCell DeathMacromolecular SynthesisTumor BiologyChemotherapy Sensitivity +14

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

JE Karp, R. G. Wyn Jones, CB Miller, +5

Blood