The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

Yousuke Ebina, Leland Ellis, Kurt Jarnagin, +9

Cell

Molecular PhysiologySignal TransductionBiochemistryHormone-activated Transmembrane SignallingNatural Sciences +11

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

Kyle L. Hoehn, Cordula Hohnen-Behrens, Anna Cederberg, +5

Cell Metabolism

Insulin ResistanceGeneticsDiabetesDiabetes MellitusMedicine +1

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Elaine Xu, M. Sunil Kumar, Yi Zhang, +10

Cell Metabolism

Glucagon ReleaseInsulin ManagementPhysiologyDiabetesEndocrinology +2

Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

Satoshi Ugi, Takeshi Imamura, Hiroshi Maegawa, +7

Molecular and Cellular Biology

GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay

Qinghua Wang, Zayna A. Khayat, Kazuhiro Kishi, +2

FEBS Letters

Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions

Takashi Katome, Toshiyuki Obata, Rie Matsushima, +6

Journal of Biological Chemistry

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

Davide Lauro, Yoshiaki Kido, Arthur L. Castle, +4

Nature Genetics

ObesityInsulin ResistanceMetabolic SyndromeKinesiologyBody Composition +13

Human Diabetes Associated with a Deletion of the Tyrosine Kinase Domain of the Insulin Receptor

Masato Taira, Masanori Taira, Naotake Hashimoto, +8

Science

Insulin ResistanceMetabolic SyndromeInsulin SignalingSignal TransductionHealth Sciences +13

GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity

Atsunori Ueyama, Karen Yaworsky, Qinghua Wang, +2

American Journal of Physiology-Endocrinology and Metabolism

Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

Asako Minami, Masanori Iseki, Kazuhiro Kishi, +14

Diabetes

Insulin ReceptorInsulin SignalingMetabolic SyndromeAps Knockout MiceInsulin Delivery +14