Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

Nobuhiko Kamada, Tadakazu Hisamatsu, Susumu Okamoto, +9

Journal of Clinical Investigation

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease

Taku Kobayashi, Shosuke Okamoto, Tadakazu Hisamatsu, +9

Gut

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

Tetsuro Takayama, Nobuhiko Kamada, Hiroshi Chinen, +10

Gastroenterology

InflammationChronic Inflammatory DiseasesMucosal ImmunologyInnate Immune SystemImmunology +7

Th1/Th17 Immune Response Is Induced by Mesenteric Lymph Node Dendritic Cells in Crohn's Disease

Atsushi Sakuraba, Toshiro Sato, Nobuhiko Kamada, +3

Gastroenterology

InflammationMucosal ImmunologyImmunologyImmune RegulationPathology +4

<scp>TGR</scp>5 signalling inhibits the production of pro‐inflammatory cytokines by <i>in vitro</i> differentiated inflammatory and intestinal macrophages in Crohn's disease

Kazuaki Yoneno∥, Tadakazu Hisamatsu, Katsuyoshi Shimamura, +12

Immunology

Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel Disease

Tadakazu Hisamatsu, Susumu Okamoto, Masaki Hashimoto, +16

PLoS ONE

Bile acids induce monocyte differentiation toward interleukin‐12 hypo‐producing dendritic cells via a TGR5‐dependent pathway

Riko Ichikawa, Tetsuro Takayama, Kazuaki Yoneno∥, +9

Immunology

Innate Immune SystemImmunologyImmune RegulationImmunologic MechanismInnate Immunity +20

Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10–Producing Regulatory Macrophage Subset

Yasuhiro Takada, Tadakazu Hisamatsu, Nobuhiko Kamada, +11

The Journal of Immunology

Chronic Inflammatory DiseasesIntestinal InflammationImmunologyImmune RegulationInnate Immunity +19

Mucosal CXCR4⁺ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation

Michihide Uo, Tadakazu Hisamatsu, Jun Miyoshi, +9

Gut

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease

Nobuhiko Kamada, Tadakazu Hisamatsu, Haruki Honda, +9

Inflammatory Bowel Diseases