The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

Jacqueline E. Damen, L Liu, Patricia M. Rosten, +4

Proceedings of the National Academy of Sciences

Unique ProteinImmunologyMolecular BiologyCellular PhysiologyPhosphatidylinositol 3,4,5-Triphosphate 5-Phosphatase +15

Targeted disruption of<i>SHIP</i>leads to hemopoietic perturbations, lung pathology, and a shortened life span

Cheryl D. Helgason, Jacqueline E. Damen, Patty Rosten, +7

Genes & Development

Monomeric IgE Stimulates Signaling Pathways in Mast Cells that Lead to Cytokine Production and Cell Survival

Janet Kalesnikoff, Michael Huber, Vivian Lam, +4

Immunity

InflammationCytokine ProductionImmunogeneticsCytokineAllergy +13

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

Michael Huber, Cheryl D. Helgason, Jacqueline E. Damen, +3

Proceedings of the National Academy of Sciences

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

Jacqueline E. Damen, Hiroshi Wakao, Atsushi Miyajima, +4

The EMBO Journal

InflammationCytokineSignal TransductionReceptor Tyrosine KinaseImmunology +9

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

Robert L. Cutler, L Liu, Jacqueline E. Damen, +1

Journal of Biological Chemistry

Signal Transduction PathwaysImmunologyBlood CellInflammationSteel Factor +16

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

Lin Liu, Jacqueline E. Damen, Robert L. Cutler, +1

Molecular and Cellular Biology

ImmunologyImmune RegulationMolecular BiologySignal RecognitionCommon 145-Kilodalton Protein +22

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP

George Chacko, Susheela Tridandapani, Jacqueline E. Damen, +3

The Journal of Immunology

Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473

Michael P. Scheid, Michael Huber, Jacqueline E. Damen, +6

Journal of Biological Chemistry

A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity

Cheryl D. Helgason, Christian P. Kalberer, Jacqueline E. Damen, +4

The Journal of Experimental Medicine