Efficacy and safety of the histamine H4 receptor antagonist ZPL-3893787 in patients with atopic dermatitis

Thomas Werfel, Gary Layton, Michael Yeadon, +8

Journal of Allergy and Clinical Immunology

Drug HypersensitivityAllergyAtopic DermatitisMedicineImmunology +5

Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease

David S. Millan, Mark E. Bunnage, Jane L. Burrows, +15

Journal of Medicinal Chemistry

Pharmaceutical ScienceP38 InhibitorsPharmacotherapyLead SeriesMedicinal Chemistry +14

Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

Sterghios Moschos, Manfred Frick, B Keith Taylor, +25

Molecular Therapy

Inhalation by Design: Novel Ultra-Long-Acting β₂-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfonamide Agonist Headgroup

Paul A. Glossop, Charlotte A. L. Lane, David Price, +14

Journal of Medicinal Chemistry

AsthmaSulfonamide Agonist HeadgroupInflammatory Lung DiseaseLung InflammationPharmacotherapy +18

Anti-inflammatory modulation of chronic airway inflammation in the murine house dust mite model

Kristina Ulrich, Jennifer S. Hincks, Roddy Walsh, +7

Pulmonary Pharmacology & Therapeutics

InflammationAsthmaAnti-inflammatory ModulationAllergyInflammatory Lung Disease +10

Gene Expression and Immunolocalization of 15-Lipoxygenase Isozymes in the Airway Mucosa of Smokers with Chronic Bronchitis

Jie Zhu, Iain Kilty, Helen Granger, +13

American Journal of Respiratory Cell and Molecular Biology

AsthmaAcute Lung Injury15-Lo Gene15-Lipoxygenase IsozymesInflammatory Lung Disease +18

Preclinical Evaluation of an Inhibitor of Cytosolic Phospholipase A2α for the Treatment of Asthma

Christopher A. Hewson, Sheena Patel, Luigino Calzetta, +14

Journal of Pharmacology and Experimental Therapeutics

Inhalation by Design: Novel Tertiary Amine Muscarinic M₃Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Paul A. Glossop, Christine Watson, David Price, +21

Journal of Medicinal Chemistry

Induction of calcium‐independent nitric oxide synthase by allergen challenge in sensitized rat lung in vivo

Michael Yeadon, Robert Price

British Journal of Pharmacology

SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

Simon J. Mantell, Peter T. Stephenson, Sandra M. Monaghan, +14

Bioorganic & Medicinal Chemistry Letters

Inhaled A2a AgonistsMedicinePulmonary PharmacologyClinical PharmacologyClinical Pharmacokinetic Data +7