Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

Godefridus J. Peters, Emile J. Laurensse, A. Leyva, +2

PubMed

Chemoprevention StrategyPyrimidine MetabolismCellular PharmacologyPharmacotherapyExperimental Pharmacology +20

Measurement of DNA in cultured human cells

A. Leyva, William N. Kelley

Analytical Biochemistry

ChromatinHuman CellDnaCultured Human CellsCell Division +6

Adaptation of the rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia

Rob Pieters, D. R. Huismans, A. Leyva, +1

Cancer Letters

Hematological MalignancyOncologyEngineeringLaboratory HematologyMedicine +13

Comparison of the rapid automated MTT-assay with a dye exclusion assay for chemosensitivity testing in childhood leukaemia

Rob Pieters, D. R. Huismans, A. Leyva, +1

British Journal of Cancer

Hematological MalignancyOncologyLaboratory HematologyChildhood LeukaemiaMedicine +12

Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients.

C.J. van Groeningen, A. Leyva, A.M.P. O'Brien, +2

PubMed

Pharmacokinetic StudyPharmacotherapyCancer PatientsAdvanced Solid TumorsHematological Malignancy +14

Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

Godefridus J. Peters, C.J. van Groeningen, E. Laurensse, +3

Cancer Chemotherapy and Pharmacology

MedicinePhysiologyRenal InflammationTissue LevelsRenal Pathophysiology +4

Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.

A. Leyva, C.J. van Groeningen, I Kraal, +4

PubMed

Pharmacokinetic StudiesPharmaceutical ScienceUrology5-Fluorouracil ToxicityPharmacological Study +10

Decreased resistance to gemcitabine (2′,2′-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

Andries M. Bergman, Herbert M. Pinedo, A.P.M. Jongsma, +6

Biochemical Pharmacology

Altered ActivityMolecular PharmacologyHematological MalignancyDeoxycytidine KinaseMedicine +10

Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.

C.J. van Groeningen, A. Leyva, I Kraal, +2

PubMed

Intermittent Infusion ScheduleUrologyRenal FunctionPharmacologyHigh-dose Uridine +12

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil

Jerry van Dijk, E. Laurensse, CJ van Groeningen, +4

British Journal of Cancer

Medicinal ChemistryPharmaceutical ScienceBiochemistryNatural SciencesUridine 'Rescue +6