ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

Cherrie K. Donawho, Yan Luo, Yanping Luo, +34

Clinical Cancer Research

Potent and selective inhibitors of Akt kinases slow the progress of tumors <i>in vivo</i>

Yan Luo, Alexander R. Shoemaker, Xuesong Liu, +25

Molecular Cancer Therapeutics

Akt KinasesSignal Transduction PathwaysMedicinePharmacologyTumor Growth Inhibition +12

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

James W. Purcell, Sonia G. Tanlimco, Jonathan A. Hickson, +17

Cancer Research

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

En-Kun Han, Thomas McGonigal, O. Jameel Shah, +4

Oncogene

Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayCell Regulation +6

Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells

Jun Chen, Sha Jin, Stephen K. Tahir, +7

Journal of Biological Chemistry

Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-β-glucosyltransferase

Aparna V. Sarthy, Thomas McGonigal, Michael Coen, +3

Microbiology

Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways

Xuesong Liu, Edward K. Han, Mark G. Anderson, +14

Molecular Cancer Research

Abt-888 IsGeneticsMolecular BiologyCancer BiologyTumor Biology +22

Clones from the human gene complex coding for salivary proline-rich proteins.

Edwin A. Azen, Karen M. Lyons, Thomas McGonigal, +6

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyGene CharacterizationMolecular GeneticsGenomics +17

Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

Yan Shi, Xuesong Liu, Edward K. Han, +12

Neoplasia

ImmunologyOptimal ClassesPharmacotherapyImmunotherapyTumor Biology +19

Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.

Edward K. Han, Thomas McGonigal, Christopher Butler, +2

PubMed

ApoptosisImmunologyCell DeathCellular PhysiologyTumor Biology +21