E Chinje

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

Andrew P. Garner, Mark J. I. Paine, Ignacio Rodríguez‐Crespo et al. · PubMed · 1999 · 109 citations

Life Sciences, Biochemistry, Pharmacology +17

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

MP Saunders, E Chinje, DC Talbot et al. · British Journal of Cancer · 1997 · 94 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233)

HM Barham, E Chinje, GE Adams · British Journal of Cancer · 1995 · 85 citations · Full text

Medicine, Oncology, Pharmacology +10

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

Mark Saunders, Adam V. Patterson, E Chinje et al. · British Journal of Cancer · 2000 · 51 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?

E Chinje, Adam V. Patterson, Mark Saunders et al. · British Journal of Cancer · 1999 · 14 citations · Full text

Medicine, Oncology, Pharmacology +17