A Novel Association of Fc Receptor γ-Chain with Glycoprotein VI and Their Co-expression as a Collagen Receptor in Human Platelets

Masaaki Tsuji, Yasuharu Ezumi, Morio Arai, +1

Journal of Biological Chemistry

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

Morio Arai, Dorothea Scandella, Leon W. Hoyer

Journal of Clinical Investigation

InflammationFactor Viii InhibitionBiochemistryMedicineHematology +9

Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency

Morio Arai, Naomasa Yamamoto, Masaaki Moroi, +3

British Journal of Haematology

Platelet GpviImmunologyGlycoprotein ViPathologyPlatelet Pathobiology +21

Collagen-stimulated Activation of Syk but Not c-Src Is Severely Compromised in Human Platelets Lacking Membrane Glycoprotein VI

Tatsuo Ichinohe, Hiroshi Takayama, Yasuharu Ezumi, +4

Journal of Biological Chemistry

Molecular characterization of mild-to-moderate hemophilia A: detection of the mutation in 25 of 29 patients by denaturing gradient gel electrophoresis.

Miyoko Higuchi, Stylianos E. Antonarakis, L. Kasch, +6

Proceedings of the National Academy of Sciences

Molecular CharacterizationLaboratory HematologyPoint MutationsGenetic DisorderGradient Gel Electrophoresis +13

Involvement of Glycoprotein VI in Platelet Thrombus Formation on Both Collagen and von Willebrand Factor Surfaces Under Flow Conditions

Shinya Goto, Noriko Tamura, Shunnosuke Handa, +3

Circulation

Factor VIII Inhibitor Antibodies with C2 Domain Specificity Are Less inhibitory to Factor VIII Complexed with von Willebrand Factor

Suzuki Suzuki, Morio Arai, Kagehiro Amano, +2

Thrombosis and Haemostasis

Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts

Kohji Kasahara, Mizuho Kaneda, Toshiaki Miki, +14

Blood

Direct characterization of factor VIII in plasma: detection of a mutation altering a thrombin cleavage site (arginine-372----histidine).

Morio Arai, Hiroshi Inaba, Miyoko Higuchi, +4

Proceedings of the National Academy of Sciences

ImmunologyPathologyThrombosisLaboratory HematologyHematology +15

Influences of strenuous exercise (triathlon) on blood coagulation and fibrinolytic system

Morio Arai, H Yorifuji, S Ikematsu, +6

Thrombosis Research

ThrombosisPhysical ActivityKinesiologyFibrinolytic SystemExercise +10