Dorothea Scandella

A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine

Midori Shima, Dorothea Scandella, Akira Yoshioka et al. · Thrombosis and Haemostasis · 1993 · 194 citations

Pharmacy, Hematology, Molecular Biology +17

The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

Evgueni L. Saenko, Dorothea Scandella · Journal of Biological Chemistry · 1997 · 193 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

A role for the C2 domain of factor VIII in binding to von Willebrand factor

Evgueni L. Saenko, Midori Shima, K.J. Rajalakshmi et al. · Journal of Biological Chemistry · 1994 · 186 citations · Full text

Life Sciences, Molecular Biology, Clinical Immunology +16

The Inhibitor Antibody Response Is More Complex in Hemophilia A Patients Than in Most Nonhemophiliacs With Factor VIII Autoantibodies

Richard Prescott, Hiroaki Nakai, Evgueni L. Saenko et al. · Blood · 1997 · 182 citations · Full text

Medicine, Hematology, Immunology +10

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

Morio Arai, Dorothea Scandella, Leon W. Hoyer · Journal of Clinical Investigation · 1989 · 180 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14