Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

Mark J. Anderton, Howard R. Mellor, Alex Bell, +6

Toxicologic Pathology

Human GrowthPathologyPharmacotherapyCongenital Heart AnomalyCardiovascular Toxicity +14

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and <i>ESR1</i> -Mutant Breast Tumors in Preclinical Models

Hazel M. Weir, Robert H. Bradbury, Mandy Lawson, +26

Cancer Research

Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults

Maurizio Gallieni, Markus Hollenbeck, Nicholas Inston, +40

Nephrology Dialysis Transplantation

Iliocaval compression syndrom

Syde A. Taheri, Steve Powell, Julle Cullen, +4

The American Journal of Surgery

Lossy CompressionEngineeringParallel ProgrammingComputer ScienceIliocaval Compression Syndrom +2

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Urs J. Hancox, Sabina Cosulich, Lyndsey Hanson, +21

Molecular Cancer Therapeutics

Mid-term results with laser atherectomy in the treatment of infrainguinal occlusive disease

Michael C. Stoner, Dorian J. deFreitas, Sachin V. Phade, +3

Journal of Vascular Surgery

Infrainguinal Occlusive DiseaseMid-term ResultsOphthalmologyOculoplasticsVascular Surgery +4

Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic–Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104

James Yates, Susan Ashton, Darren A.E. Cross, +3

Molecular Cancer Therapeutics

PharmacotherapyTumor BiologyPharmacodynamic ModelingTranslational PharmacologyMolecular Pharmacology +18

Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses

Anthony Cutts, Surinder M. Soond, Steve Powell, +1

The International Journal of Biochemistry & Cell Biology

Developmental BiologySignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +7

RNA-Seq Differentiates Tumour and Host mRNA Expression Changes Induced by Treatment of Human Tumour Xenografts with the VEGFR Tyrosine Kinase Inhibitor Cediranib

James Bradford, Matthew R. Farren, Steve Powell, +10

PLoS ONE

PathologyTranscriptomics TechnologyPre-clinical ModelsCancer BiologyGene Expression Profiling +21

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

M. Raymond V. Finlay, Mark J. Anderton, Andrew Bailey, +32

Journal of Medicinal Chemistry

Oral BioavailabilityPharmacotherapyGls1 Inhibitor Bis-2-Pharmaceutical ChemistryMedicinal Chemistry +14