Homology Modeling of Lanosterol 14α-Demethylase of<i>Candida albicans</i>and<i>Aspergillus fumigatus</i>and Insights into the Enzyme-Substrate Interactions

Chunquan Sheng, Wannian Zhang, Min Zhang, +8

Journal of Biomolecular Structure and Dynamics

Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants

Chao Hu, Meiying Shen, Xiaojian Han, +17

Genes & Diseases

Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs

Shuai Li, Xinyang Li, Tingjian Zhang, +4

Bioorganic Chemistry

Medicinal ChemistryDerivative (Chemistry)BiochemistryMedicineNatural Sciences +10

Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors

Shuai Li, Xinyang Li, Tingjian Zhang, +4

Bioorganic Chemistry

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)BiochemistryErythrina Derivatives +8

Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides

Tai Shun Lin, Jü Zhu, Ginger E. Dutschman, +2

Journal of Medicinal Chemistry

Bioorganic ChemistryImmunologyOrganic ChemistryAntiviral DrugPharmaceutical Chemistry +14

Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity

Canhui Zheng, Hui Yang, Meng Zhang, +9

Bioorganic & Medicinal Chemistry Letters

Tumor BiologyDrug TargetMedicineActivity EvaluationRational Drug Design +7

Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma

Ruolan Zhou, Shao‐Yu Fang, Minmin Zhang, +8

Bioorganic & Medicinal Chemistry Letters

Hematological MalignancyMedicinal ChemistryOncologyBioactivity EvaluationMedicine +7

Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method

Can-Hui Zheng, You-Jun Zhou, Jü Zhu, +8

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDrug TargetBiochemistryFlexible DockingMedicine +9

Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity

Chao Yang, Hui Chen, Shihai Lu, +9

Bioorganic & Medicinal Chemistry Letters

EngineeringFlos ChrysanthemiBiochemistryChemoprevention StrategyMedicine +8

ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway

Wei Huang, Jü Zhu, Haoming Shi, +2

OncoTargets and Therapy