The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel’s active metabolite

Atsuhiro Sugidachi, Taketoshi Ogawa, Atsushi Kurihara, +5

Journal of Thrombosis and Haemostasis

Molecular PharmacologyThrombosisEfficient GenerationBiochemistryBlood Platelet +6

Prolonged Mild Hypothermia Therapy Protects the Brain Against Permanent Focal Ischemia

Hiroji Yanamoto, Izumi Nagata, Y. Niitsu, +4

Stroke

Mild Hypothermia TherapyCerebrovascular DiseaseCerebral Vascular RegulationIntracranial PressureBrain Injury +20

Exposure of cultured primary rat astrocytes to hypoxia results in intracellular glucose depletion and induction of glycolytic enzymes

Y. Niitsu, Osamu Hori, Atsushi Yamaguchi, +5

Molecular Brain Research

PhysiologyDiabetesCultured Primary RatHypoxia (Medicine)Glycolytic Enzymes +8

Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species

Y. Niitsu, Atsuhiro Sugidachi, Taketoshi Ogawa, +5

European Journal of Pharmacology

ThrombopoiesisThrombosisPlatelet Aggregation InhibitorsBlood PlateletRepeat Oral Dosing +8

Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo

Y. Niitsu, Shun Hatnada, Kayoko Hamaguchi, +2

Neuroscience Letters

Synaptic PlasticityChicken EmbryoDevelopmental BiologyNeuroanatomySynapse Density +9

The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: Evidence for specific inhibition of P2Y12 receptors by prasugrel

Masami Hashimoto, Atsuhiro Sugidachi, Takashi Isobe, +4

Biochemical Pharmacology

ThrombopoiesisThrombosisPlatelet Aggregation InhibitorsSignal TransductionBlood Platelet +10

Ministrokes in Channelrhodopsin-2 Transgenic Mice Reveal Widespread Deficits in Motor Output Despite Maintenance of Cortical Neuronal Excitability

Eitan Anenberg, Pamela Arstikaitis, Y. Niitsu, +5

Journal of Neuroscience

Motor ControlNeurotransmissionCerebral Vascular RegulationStroke RehabilitationMotor Output +28

Effects of prasugrel, a novel P2Y12 inhibitor, in rat models of cerebral and peripheral artery occlusive diseases

Taketoshi Ogawa, Masami Hashimoto, Y. Niitsu, +5

European Journal of Pharmacology

MedicinePhysiologyRat ModelsNeuropharmacologyVascular Biology +10

Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure-Activity Relationships of Cinnamyl Derivatives

Tetsuji Noguchi, Naoki Tanaka, Toyoki Nishimata, +8

Chemical and Pharmaceutical Bulletin

Selective Blockade of P2Y12 Receptors by Prasugrel Inhibits Myocardial Infarction Induced by Thrombotic Coronary Artery Occlusion in Rats

Atsuhiro Sugidachi, Shinji Yamaguchi, Joseph A. Jakubowski, +4

Journal of Cardiovascular Pharmacology

Cardiovascular PharmacologyPharmacotherapyPlatelet AggregationInflammationThrombosis +16