V C Knick

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

Brian E. Huber, Elizabeth A. Austin, Steven S. Good et al. · PubMed · 1993 · 230 citations

Medicine, Oncology, Pharmacology +13

Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line.

Q T Trinh, Elizabeth A. Austin, Doris M. Murray et al. · PubMed · 1995 · 173 citations

Medicine, Oncology, Pharmaceutical Biotechnology +10

5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.

David P. Baccanari, Stephen T. Davis, V C Knick et al. · Proceedings of the National Academy of Sciences · 1993 · 130 citations

Medicine, Pharmacokinetics, Pharmacology +17

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.

David S. Duch, Sheila D. Banks, I K Dev et al. · PubMed · 1993 · 114 citations

Life Sciences, Biochemistry, Pharmacology +9

High-Affinity Inhibitors of Dihydrofolate Reductase:  Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-<i>f</i>]quinazolines with Small Molecular Size

Lee F. Kuyper, David P. Baccanari, Michael L. Jones et al. · Journal of Medicinal Chemistry · 1996 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15