Pamella J. Ford

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

Woods Wannamaker, Robert M. D. Davies, Mark Namchuk et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 319 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control

Alex M. Aronov, Qing Tang, Gabriel Martínez-Botella et al. · Journal of Medicinal Chemistry · 2009 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

Ted Fox, Joyce T. Coll, Xiaoling Xie et al. · Protein Science · 1998 · 135 citations

Life Sciences, Molecular Biology, Pharmacology +13

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

Ursula A. Germann, Pamella J. Ford, Dina Shlyakhter et al. · Anti-Cancer Drugs · 1997 · 132 citations

Medicine, Oncology, Pharmacology +15

Flipped Out:  Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors

Alex M. Aronov, Christopher Baker, Guy W. Bemis et al. · Journal of Medicinal Chemistry · 2007 · 122 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17