Jane R. Engler

OCT-1–mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

Deborah L. White, Verity A Saunders, Phuong Dang et al. · Blood · 2006 · 432 citations · Full text

Life Sciences, Cell Biology, Pharmacology +6

Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity

Deborah L. White, Verity A Saunders, Phuong Dang et al. · Blood · 2007 · 331 citations

Medicine, Hematology, Pharmacology +2

Functional Activity of the OCT-1 Protein Is Predictive of Long-Term Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib

Deborah L. White, Phuong Dang, Jane R. Engler et al. · Journal of Clinical Oncology · 2010 · 183 citations

Medicine, Hematology, Pharmacology +11

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

Jane R. Engler, Aaron E. Robinson, Ivan Smirnov et al. · PLoS ONE · 2012 · 165 citations · Full text

Medicine, Immunology, Oncology +17

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity

Olle R. Lindberg, Andrew McKinney, Jane R. Engler et al. · Oncotarget · 2016 · 42 citations · Full text

Medicine, Cancer Biology, Oncology +17