David Filpula

A Novel, Highly Stable Fold of the Immunoglobulin Binding Domain of Streptococcal Protein G

Angela M. Gronenborn, David Filpula, Nina Z. Essig et al. · Science · 1991 · 818 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

Diane E. Milenic, Takashi Yokota, David Filpula et al. · PubMed · 1991 · 340 citations

Single-chain Fv, Tumor Biology, Dimeric F +12

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability

M. Whitlow, Brian Bell, Sheau-Line Feng et al. · Protein Engineering Design and Selection · 1993 · 305 citations

Single-chain Fv, Electrical Engineering, Improved Linker +15

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

Lee M. Greenberger, Ivan D. Horak, David Filpula et al. · Molecular Cancer Therapeutics · 2008 · 237 citations · Full text

Tumor Biology, Transcriptional Regulation, Tumor Cell Growth +15

Structure−Function Engineering of Interferon-β-1b for Improving Stability, Solubility, Potency, Immunogenicity, and Pharmacokinetic Properties by Site-Selective Mono-PEGylation

Amartya Basu, Karen Yang, Maoliang Wang et al. · Bioconjugate Chemistry · 2006 · 213 citations

Ethylene Glycol, Immunology, Structure−function Engineering +22