Donald E. Slaughter

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s.

Thomayant Prueksaritanont, Lynn M. Gorham, Bennett Ma et al. · PubMed · 1997 · 271 citations

Medicine, Biochemistry, Pharmacology +17

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin et al. · Journal of Medicinal Chemistry · 2008 · 156 citations · Full text

Medicine, Oncology, Pharmacology +13

MECHANISM-BASED INHIBITION OF HUMAN LIVER MICROSOMAL CYTOCHROME P450 1A2 BY ZILEUTON, A 5-LIPOXYGENASE INHIBITOR

Ping Lü, Michael Schrag, Donald E. Slaughter et al. · Drug Metabolism and Disposition · 2003 · 105 citations

Medicine, Pharmacokinetics, Pharmacology +16

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current <i>I</i>_Ks by (<i>R</i>)-2-(2,4- Trifluoromethyl)-<i>N</i>-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-3-yl]acetamide

Harold G. Selnick, Nigel J. Liverton, John J. Baldwin et al. · Journal of Medicinal Chemistry · 1997 · 95 citations · Full text

Medicine, Cardiology, Pharmacology +10

Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles

Donald E. Slaughter, Robert P. Hanzlik · Chemical Research in Toxicology · 1991 · 64 citations

Pharmacy, Chemistry, Toxicology +6