Development of a supersaturable SEDDS (S‐SEDDS) formulation of paclitaxel with improved oral bioavailability

Ping Gao, B.D. Rush, William P. Pfund, +5

Journal of Pharmaceutical Sciences

Pharmaceutical ScienceImproved Oral BioavailabilityMedicineSupersaturable SeddsPharmacotherapy +4

Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

René L. Jacobs, Yang Zhao, Debby P.Y. Koonen, +10

Journal of Biological Chemistry

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

Zhiqiang Li, Hongqi Zhang, Jing Liu, +13

Molecular and Cellular Biology

Metabolic DisorderSphingolipid Synthesis IncreasesInsulin SignalingObesityMetabolic Syndrome +16

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells

Bo Tan, Debra A. Young, Zhao-Hai Lu, +13

Journal of Biological Chemistry

GlycobiologyNad+ BiosynthesisMetabolic RemodelingPharmacological InhibitionSerine Biosynthesis +17

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

Tiruneh Hailemariam, Chongmin Huan, Jing Liu, +9

Arteriosclerosis Thrombosis and Vascular Biology

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

Jing Liu, Chongmin Huan, Mahua Chakraborty, +5

Circulation Research

AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase

Yan Chen, Ming‐Shang Kuo, Shuyu Li, +13

Journal of Biological Chemistry

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

Andrew M. Sawayama, Michael M. Y. Chen, Palaniappan Kulanthaivel, +3

Chemistry - A European Journal

Drug Lead DiversificationEngineeringMetabolomic ProfilingCytochrome P450 Bm3Drug Metabolites +15

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization

Zhiqiang Li, Tiruneh Hailemariam, Hongwen Zhou, +7

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Proteinlipid InteractionMolecular PhysiologySignal TransductionBiochemistryNatural Sciences +9

Glucocerebrosidase 1 deficient<i>Danio rerio</i>mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

Marcus Keatinge, Hai H. Bui, Aswin Menke, +23

Human Molecular Genetics