Sílvia R.P. Miranda

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

Yutaka Morita, Gloria I. Perez, François Paris et al. · Nature Medicine · 2000 · 594 citations

Signal Transduction, Acid Sphingomyelinase Gene, Apoptosis +9

Infusion of recombinant human acid sphingomyelinase into Niemann‐Pick disease mice leads to visceral, but not neurological, correction of the pathophysiology

Sílvia R.P. Miranda, Xingxuan He, Calogera M. Simonaro et al. · The FASEB Journal · 2000 · 140 citations

Pathology, Experimental Pathology, Disease Physiology +16

Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells

Xingxuan He, Sílvia R.P. Miranda, Xiaoling Xiong et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1999 · 99 citations

Human Acid Sphingomyelinase, Biochemistry, Natural Sciences +7

Patterned cerebellar Purkinje cell death in a transgenic mouse model of Niemann Pick type A/B disease

Justyna R. Sarna, Sílvia R.P. Miranda, Edward H. Schuchman et al. · European Journal of Neuroscience · 2001 · 94 citations

Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann–Pick disease

Sílvia R.P. Miranda, Shai Erlich, Victor L. Friedrich et al. · Gene Therapy · 2000 · 58 citations

Neurodegenerative Diseases, Neuroregeneration, Visceral Organ Improvements +12