Stephen G Pacholok

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-<i>t</i>-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

John W. Gillard, A W Ford‐Hutchinson, Chi-Chung Chan et al. · Canadian Journal of Physiology and Pharmacology · 1989 · 328 citations

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

Richard C. Hubbard, G A Fells, James E. Gadek et al. · Journal of Clinical Investigation · 1991 · 214 citations · Full text

Acute Lung Injury, Asthma, Inflammatory Lung Disease +20

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

William K. Hagmann, Charles G. Caldwell, Ping Chen et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 46 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +7

Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

Christopher A. Willoughby, Steven M. Hutchins, Keith G. Rosauer et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 43 citations

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

K. Shankaran, Karla L. Donnelly, Shrenik K. Shah et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 37 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +11