A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits

Hiroshi Okamoto, Fumihiko Yonemori, Korekiyo Wakitani, +3

Nature

Metabolic SyndromeOxysterolBiochemistryCardiovascular DiseaseMedicine +10

4-(4-Cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as Selective Cyclooxygenase-2 Inhibitors:  Enhancement of the Selectivity by Introduction of a Fluorine Atom and Identification of a Potent, Highly Selective, and Orally Active COX-2 Inhibitor JTE-522

Hiromasa Hashimoto, Katsuaki Imamura, Jun‐ichi Haruta, +1

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapySelective Cyclooxygenase-2 InhibitorsPharmaceutical ChemistryMedicinal Chemistry +15

Effects of peroxisome proliferator‐activated receptor‐α and ‐γ agonist, JTT‐501, on diabetic complications in Zucker diabetic fatty rats

Tsutomu Shibata, Satomi Takeuchi, Seiko Yokota, +3

British Journal of Pharmacology

Isoxazolidine-3,5-dione and Noncyclic 1,3-Dicarbonyl Compounds as Hypoglycemic Agents

Hisashi Shinkai, Syoji Onogi, Masahiro Tanaka, +4

Journal of Medicinal Chemistry

Pharmaceutical ScienceNoncyclic 1,3-Dicarbonyl CompoundsOrganic ChemistryPharmacotherapyChemical Derivative +14

Pharmacological Studies on the TXA2 Synthetase Inhibitor (E)-3-[p(1H-lmidazol-1-Ylmethyl)Phenyl]-2-Propenoic Acid (OKY-046)

Seiji HIRAKU, Ken Taniguchi, Korekiyo Wakitani, +6

The Japanese Journal of Pharmacology

Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative

Tsutomu Shibata, Kenichi Matsui, Kaori Nagao, +3

European Journal of Pharmacology

Pharmacological ProfilesPharmaceutical SciencePharmacological StudyDiabetesPharmacology +5

Profile of JTE-522 as a Human Cyclooxygenase-2 Inhibitor

Korekiyo Wakitani, Toyomichi Nanayama, M. Masaki, +1

The Japanese Journal of Pharmacology

Chemoprevention StrategyImmunologyHuman Cyclooxygenase-2 InhibitorPharmacotherapyOxidative Stress +16

Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain–hypothalamic neural pathways in rats

Nobuya Ogawa, Makoto Ito, Hideki Yamaguchi, +5

Metabolism

Caloric RestrictionNutritionObesityMidbrain–hypothalamic Neural PathwaysAppetite Control +12

Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animals

Hiroshi Okamoto, Y Iwamoto, Mimi Maki, +3

European Journal of Pharmacology

Animal PhysiologyMetabolic SyndromeLipid AnalysisPlasma Lipid LevelsBiochemistry +9

Synthesis and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-4<i>H</i>-thieno[3,2-<i>b</i>]azepine Derivatives:  Novel Arginine Vasopressin Antagonists

Hidetsura Cho, Kengo Murakami, H. Nakanishi, +9

Journal of Medicinal Chemistry

HypertensionOrganic ChemistryPharmacotherapyChemistryPharmaceutical Chemistry +15