Histone demethylation by a family of JmjC domain-containing proteins

Yu-ichi Tsukada, Jia Fang, Hediye Erdjument‐Bromage, +4

Nature

Histone ModificationsChromatinChromatin RemodelingNatural SciencesEpigenetic Change +7

Role of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene Silencing

Ru Cao, Yu-ichi Tsukada, Yi Zhang

Molecular Cell

Hox Gene SilencingChromatinGeneticsGenomic MechanismGene Regulation +8

JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor

Kenichi Yamane, Charalambos Toumazou, Yu-ichi Tsukada, +4

Cell

Androgen ReceptorNatural SciencesEpigenetic ChangeHormonal ReceptorMolecular Biology +9

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

Jin He, Eric M. Kallin, Yu-ichi Tsukada, +1

Nature Structural & Molecular Biology

Signaling PathwayCell RegulationCellular SenescenceCell ProliferationEpigenetics +5

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Masaaki Nishiyama, Kiyotaka Oshikawa, Yu-ichi Tsukada, +7

Nature Cell Biology

ChromatinHistone H1 RecruitmentDevelopmental BiologyChromatin RemodelingEpigenetic Change +10

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Yu-ichi Tsukada, Tohru Ishitani, Keiichi I. Nakayama

Genes & Development

Histone ModificationsKdm7 OrthologsLys 27Brain DevelopmentEpigenetic Change +16

Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons

Yuki Hatanaka, Kimiko Inoue, Mami Oikawa, +6

Proceedings of the National Academy of Sciences

Preimplantation Mouse EmbryosEpigenetic ChangeGeneticsDna MethylationGenomic Mechanism +18

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Kazue Someya, Hiroko Nakatsukasa, Minako Ito, +9

International Immunology

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Yu-ichi Tsukada, Tomohiko Akiyama, Keiichi I. Nakayama

Scientific Reports

Neonatal GrowthEpigenetic ChangeGeneticsDna MethylationEpigenetics +20

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Hiroko Nakatsukasa, Mayumi Oda, Jinghua Yin, +15

International Immunology

Lymphocyte DevelopmentT-regulatory CellImmunologyImmune RegulationPathology +15