Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Susan P.C. Cole, Gabu Bhardwaj, James H. Gerlach, +7

Science

Gene AmplificationTumor MicroenvironmentOncogenic AgentMedicineTransporter Gene +13

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Inka Leier, Gabriele Jedlitschky, Ulrike Buchholz, +3

Journal of Biological Chemistry

Proteinlipid InteractionAtp-dependent Ltc4 TransportMolecular BiologyMrp GeneTumor Biology +16

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

Caroline E. Grant, Gunnar Valdimarsson, David R. Hipfner, +3

PubMed

ImmunologyPharmacotherapySystem PharmacologyTumor BiologyDrug Resistance +17

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

Douglas W. Loe, R G Deeley, Susan P.C. Cole

PubMed

Molecular PharmacologyProteinlipid InteractionDrug Resistance AnalysisBiochemistryMedicine +13

Primary activation of the vitellogenin gene in the rooster.

R G Deeley, Jeffrey I. Gordon, A.T. Burns, +2

Journal of Biological Chemistry

GeneticsMolecular GeneticsReproductive BiologyVitellogenin Messenger RnaProtein Synthesis +16

Vitellogenin synthesis in the avian liver. Vitellogenin is the precursor of the egg yolk phosphoproteins

R G Deeley, DP Mullinix, Waldemar Wetekam, +4

Journal of Biological Chemistry

Egg Yolk PhosphoproteinsSynthetic VirologyImmunologyMolecular WeightsReproductive Biology +15

Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels.

Leah C. Young, Barbara G. Campling, Susan P.C. Cole, +2

PubMed

Mrp3 Protein LevelsCancer BiologyTumor BiologyDrug ResistanceOncology +15

Coordinate regulation of two estrogen-dependent genes in avian liver.

R Wiskocil, P Bensky, William J. Dower, +3

Proceedings of the National Academy of Sciences

BiologyTranscriptional RegulationNatural SciencesGeneticsHormonal Receptor +9

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

Leah C. Young, Barbara G. Campling, Theodora Voskoglou-Nomikos, +3

PubMed

Tumor BiologyMrp Mrna LevelsHealth SciencesMedicinePharmacology +13

Effects of estrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2.

S P Tam, Trevor Archer, R G Deeley

Journal of Biological Chemistry