MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells

Elena Catalán, Seyma Charni, Paula Jaime, +5

OncoImmunology

Lymphocyte DevelopmentImmunologyImmune RegulationNk CellsImmunoediting +19

Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

Sunil S. Metkar, Baikun Wang, Elena Catalán, +4

PLoS ONE

Proteinlipid InteractionImmunologyCell DeathCytoskeletonLipid Movement +18

HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes

N. Núñez‐Andrade, Salvador Iborra, Antonio Trullo, +9

Journal of Cell Science

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors

Adriana Aporta, Elena Catalán, Patricia Galán‐Malo, +8

Biochemical Pharmacology

Cell AutophagyMitophagyMedicineAutophagy Regulator Atg5Apoptosis +10

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity

Alberto Anel, Elena Catalán, Johan Garaude, +3

Frontiers in Immunology

Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb

Aizea Morales‐Kastresana, Elena Catalán, Sandra Hervás‐Stubbs, +6

Journal for ImmunoTherapy of Cancer

Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion

Elena Catalán, Paula Jaime‐Sánchez, Nacho Aguiló, +3

Journal of Biological Chemistry

Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase‐dependent NADPH oxidase activation

Alberto Anel, Elena Catalán, Álvaro Sebastián, +5

Immunology and Cell Biology

Cytotoxic T CellsImmunologyCell DeathMolecular BiologyMitochondrial Biology +18

Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance

Paula Jaime‐Sánchez, Elena Catalán, Iratxe Uranga-Murillo, +6

Cell Death and Differentiation

Cytotoxic T CellsT-regulatory CellImmunologyTumor ImmunityTumour Development +10

IFNα signaling through PKC-θ is essential for antitumor NK cell function

Natalia R Comet, Moeez Rathore, Elena Catalán, +6

OncoImmunology