Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: isolation, structure determination, synthesis, and biological activity

Kiyotake Suenaga, Tsuyoshi Mutou, Takunobu Shibata, +8

Tetrahedron

BiologyBiological ActivityMarine BiotechnologyBiochemistryCytotoxic Depsipeptide +6

Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia

Kiyotake Suenaga, Tsuyoshi Mutou, Takunobu Shibata, +3

Tetrahedron Letters

BiologyMarine BiotechnologyEngineeringNovel CyclodepsipeptideMicrobiology +2

Dolastatin H and Isodolastatin H, Potent Cytotoxic Peptides from the Sea Hare <i>Dolabella auricularia</i>:  Isolation, Stereostructures, and Synthesis

Hiroki Sone, Takunobu Shibata, Tatsuya Fujita, +2

Journal of the American Chemical Society

BiologyMolecular PharmacologyMedicinal ChemistryMarine BiotechnologyDolastatin H +12

(9<i>S</i>)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1<i>H</i>-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist

Nagaaki Sato, Makoto Jitsuoka, Takunobu Shibata, +12

Journal of Medicinal Chemistry

Dolabelides C and D, Cytotoxic Macrolides Isolated from the Sea Hare <i>Dolabella auricularia</i>

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, +2

Journal of Natural Products

BiologyMarine BiotechnologyBioorganic ChemistryAntiparasitic AgentNmr Technique +9

Design and Synthesis of the Potent, Orally Available, Brain-Penetrable Arylpyrazole Class of Neuropeptide Y5 Receptor Antagonists

Nagaaki Sato, Toshiyuki Takahashi, Takunobu Shibata, +12

Journal of Medicinal Chemistry

Orally AvailableGastrointestinal Peptide HormoneBiochemistryFunctional SelectivityMedicine +11

Aurilol, a Cytotoxic Bromotriterpene Isolated from the Sea Hare <i>Dolabella auricularia</i>

Kiyotake Suenaga, Takunobu Shibata, Noboru Takada, +2

Journal of Natural Products

BiologyMarine BiotechnologyBioorganic ChemistryBiochemistryHela S3 Cells +8

Stereochemistry and total synthesis of dolastatin E

Masayuki NAKAMURA, Takunobu Shibata, Kimitoshi Nakane, +3

Tetrahedron Letters

BiochemistryTotal SynthesisStereoselective SynthesisNatural Product SynthesisSynthetic Chemistry

Novel potent neuropeptide Y Y5 receptor antagonists: Synthesis and structure–activity relationships of phenylpiperazine derivatives

Toshiyuki Takahashi, Aya Sakuraba, Tomoko Hirohashi, +10

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicineReceptor (Biochemistry)Neuropeptide Receptor +8

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists

Toshiyuki Takahashi, Yuji Haga, Toshihiro Sakamoto, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineMechanism Of Action +6