Concepedia

Dolabelides C and D, Cytotoxic Macrolides Isolated from the Sea Hare <i>Dolabella auricularia</i>

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, Hideo Kigoshi, Kiyoyuki Yamada

Journal of Natural Products · 1997 · 40 citations · 4 references

DOI

Concepts

Abstract

Two new cytotoxic 24-membered macrolides, dolabelides C and D, were isolated from the Japanese sea hare Dolabella auricularia . Their gross structures were deduced by spectroscopic analysis including the 2D NMR technique, and their absolute stereochemistry was determined by means of chemical correlation with the known dolabelide A. Dolabelides C and D exhibited cytotoxicities against HeLa S 3 cells with IC 50 values of 1.9 and 1.5 μg/mL, respectively.

References

4

Aplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai

Kiyoyuki Yamada, Makoto Ojika, Takeshi Ishigaki et al. · Journal of the American Chemical Society · 1993 · 153 citations

, , +7

Absolute Stereochemistry of Aplyronine A, a Potent Antitumor Substance of Marine Origin

Makoto Ojika, Hideo Kigoshi, Takeshi Ishigaki et al. · Journal of the American Chemical Society · 1994 · 90 citations

, , +10

Dolabellin, a Cytotoxic Bisthiazole Metabolite from the Sea Hare Dolabella auricularia: Structural Determination and Synthesis

Hiroki Sone, Takashi Kondo, Minoru Kiryu et al. · The Journal of Organic Chemistry · 1995 · 85 citations

, , +11

Dolastatin H and Isodolastatin H, Potent Cytotoxic Peptides from the Sea Hare <i>Dolabella auricularia</i>:  Isolation, Stereostructures, and Synthesis

Hiroki Sone, Takunobu Shibata, Tatsuya Fujita et al. · Journal of the American Chemical Society · 1996 · 61 citations

, , +13