Izuru Ando

Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida et al. · Journal of Medicinal Chemistry · 2006 · 146 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Bioorganic Chemistry +15

Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages

Izuru Ando, Yoshinori Tsukumo, Tetsuya Wakabayashi et al. · International Immunopharmacology · 2002 · 132 citations

Inflammation, Cytokine, Allergy +13

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Tomio Ishida, Takayoshi Suzuki, Shintaro Hirashima et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 129 citations · Full text

Biochemistry, Medicine, Antiviral Drug Development +8

Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

Kazutaka Ikegashira, Takahiro Oka, Shintaro Hirashima et al. · Journal of Medicinal Chemistry · 2006 · 110 citations · Full text

Combinatorial Chemistry, Biochemistry, Medicine +11

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety

Shintaro Hirashima, Takahiro Oka, Kazutaka Ikegashira et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 37 citations

Biochemistry, 2-Morpholinophenyl Moiety, Natural Sciences +8