Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, +380

The Lancet

Interim AnalysisMetabolic Associated SteatohepatitisHepatologyPlacebo-controlled Phase 3Nonalcoholic Fatty Liver Disease +5

Budesonide Induces Remission More Effectively Than Prednisone in a Controlled Trial of Patients With Autoimmune Hepatitis

Michael P. Manns, Marek Woynarowski, Wolfgang Kreisel, +12

Gastroenterology

InflammationAutoimmune DiseaseHepatologyControlled TrialImmunosuppressive Therapy +12

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

Andreas E. Kremer, Job J.W.W. Martens, Wim Kulik, +12

Gastroenterology

Animal PhysiologyOxysterolMedicinePhysiologyLysophosphatidic Acid +3

Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas

Hideyuki Miyoshi, Christian Rust, Patricia J. Roberts, +2

Gastroenterology

HepatologyBiliary TractMedicineLiver PhysiologyApoptosis +11

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

Andreas E. Kremer, Remco van Dijk, Pamela Leckie, +13

Hepatology

Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis

Shiho Natori, Christian Rust, Linda Stadheim, +3

Journal of Hepatology

HepatologyLiver PhysiologyImmunologyHepatocyte ApoptosisHepatitis +10

A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

Kris V. Kowdley, Velimir A. Luketic, Roger W. Chapman, +14

Hepatology

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum, André Franke, Christoph Schramm, +40

Nature Genetics

Disease EtiologyImmunologyGenetic EpidemiologyPathologyCholangiopathies +14

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

Trine Folseraas, Espen Melum, Philipp Rausch, +37

Journal of Hepatology

Genome-wide Association StudyDisease SusceptibilityAutoimmune DiseaseMolecular EpidemiologyDisease Etiology +10

Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis

Lars P. Bechmann, Peri Kocabayoglu, Jan‐Peter Sowa, +14

Hepatology