Hirotoshi Matsuura

Discovery of a Structurally Novel Opioid .KAPPA.-Agonist Derived from 4,5-Epoxymorphinan.

Hiroshi Nagase, Jun Hayakawa, Kuniaki Kawamura et al. · Chemical and Pharmaceutical Bulletin · 1998 · 187 citations · Full text

Molecular Pharmacology, Biochemistry, Medicine +12

The in vitro and ex vivo antiplatelet effect of TRK-100, a stable prostacyclin analog, in several species.

Shintaro Nishio, Hirotoshi Matsuura, Noriko Kanai et al. · The Japanese Journal of Pharmacology · 1988 · 99 citations · Full text

Immunology, Pharmacotherapy, Platelet Aggregation +20

Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

Takashi Endoh, Hirotoshi Matsuura, Atsushi Tajima et al. · Life Sciences · 1999 · 98 citations

Molecular Pharmacology, Pain Disorders, Health Sciences +13

Design, synthesis, and structure–activity relationship of novel opioid κ-agonists

Koji Kawai, Jun Hayakawa, Toru Miyamoto et al. · Bioorganic & Medicinal Chemistry · 2008 · 74 citations · Full text

Structure–activity Relationship, Molecular Pharmacology, Biochemistry +9

Rational Drug Design and Synthesis of a Highly Selective Nonpeptide .DELTA.-Opioid Agonist, (4aS*,12aR*)-4a-(3-Hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).

Hiroshi Nagase, Koji Kawai, Jun Hayakawa et al. · Chemical and Pharmaceutical Bulletin · 1998 · 72 citations · Full text

Selective Non-peptide Agonists, Peptide Science, Pharmacotherapy +19