Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

Leonardo Salmena, Bénédicte Lemmers, Anne Hakem, +13

Genes & Development

Targeted Caspase 8T-regulatory CellApoptosisImmunologyCell Death +15

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

Satoshi Inoue, Wanda Y. Li, Alan Tseng, +35

Cancer Cell

Genome InstabilityDna DamageAlters Dna RepairNatural SciencesGenetics +8

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

Bénédicte Lemmers, Leonardo Salmena, Nicolas Bidère, +8

Journal of Biological Chemistry

Innate Immune SystemImmunologyCell DeathImmunologic MechanismCd4 T Cell Responses +20

Caspase-3-Dependent β-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus

Nicole Liadis, Kiichi Murakami, Mohamed Eweida, +6

Molecular and Cellular Biology

T-regulatory CellApoptosisImmunologyImmune RegulationCell Death +17

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

Linh T. Nguyen, Alisha R. Elford, Kiichi Murakami, +5

The Journal of Experimental Medicine

Notch Shapes the Innate Immunophenotype in Breast Cancer

Qiang Shen, Brenda Cohen, Weiyue Zheng, +9

Cancer Discovery

Shp1 regulates T cell homeostasis by limiting IL-4 signals

Dylan Johnson, Lily Pao, Salim Dhanji, +3

The Journal of Experimental Medicine

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyImmune Regulation +21

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

Dilan Dissanayake, Håkan Hall, Nancy N. Berg-Brown, +6

Nature Medicine

InflammationAutoimmune DiseaseImmune Cell DevelopmentImmune RegulationImmunology +13

Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer

Arushi Jaiswal, Kiichi Murakami, Andrew Elia, +6

Proceedings of the National Academy of Sciences

DNA damage- and stress-induced apoptosis occurs independently of PIDD

Ira R. Kim, Kiichi Murakami, Nien‐Jung Chen, +8

APOPTOSIS

Reductive StressGenome InstabilityDna DamageGeneticsApoptosis +5