The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge

Jessica Radzio, William Spreen, Yun Lan Yueh, +4

Science Translational Medicine

Quarterly InjectionsDaily Preexposure ProphylaxisTreatment And PreventionIntravaginal Shiv ChallengeImmunology +10

<scp>SHIV</scp> susceptibility changes during the menstrual cycle of pigtail macaques

Ellen N. Kersh, Tara Henning, Sundaram A. Vishwanathan, +11

Journal of Medical Primatology

Prevention of Vaginal SHIV Transmission in Macaques by a Coitally-Dependent Truvada Regimen

Jessica Radzio, Wutyi Aung, Angela Holder, +7

PLoS ONE

Probing nonnucleoside inhibitor‐induced active‐site distortion in HIV‐1 reverse transcriptase by transient kinetic analyses

Qing Xia, Jessica Radzio, Karen S. Anderson, +1

Protein Science

Viral ReplicationViral Polymerase StructureMolecular BiologyAntiviral DrugChemical Biology +16

Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision

Jessica Radzio, Nicolas Sluis‐Cremer

Molecular Pharmacology

Mechanisms by Which the G333D Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Facilitates Dual Resistance to Zidovudine and Lamivudine

Shannon Zelina, Chih-Wei Sheen, Jessica Radzio, +2

Antimicrobial Agents and Chemotherapy

Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques

Jessica Radzio, Krisztina Hanley, James Mitchell, +6

AIDS

Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT

Dwight V. Nissley, Jessica Radzio, Zandrea Ambrose, +5

Biochemical Journal

Molecular BiologyAntiviral DrugDrug ResistanceHuman RetrovirusResistance Mutation (Virology) +15

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Nicolas Sluis‐Cremer, Katie L. Moore, Jessica Radzio, +2

AIDS

ImmunologyPharmacotherapyAntiviral DrugEtravirine SusceptibilityDrug Resistance +14

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

Jessica Radzio, Soo Huey Yap, Gilda Tachedjian, +1

AIDS