Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

Susumu Kotani, Eiko Sakaguchi, Shogo Warashina, +7

Neuroscience Research

Alzheimer's DiseaseCognitive PerformanceBrain FunctionMedicineDementia +8

2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis

Tanihiro Yoshimoto, Chieko Yokoyama, Ochi Kenkichi, +5

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineSlow-reacting Substance +9

Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase

Tanihiro Yoshimoto, Masayuki Furukawa, Shozo Yamamoto, +2

Biochemical and Biophysical Research Communications

Medicinal ChemistryOxysterolBiochemistryNatural SciencesPhytochemical +2

The Role of 12/15-Lipoxygenase in the Expression of Interleukin-6 and Tumor Necrosis Factor-α in Macrophages

Yeshao Wen, Jiali Gu, S. K. Chakrabarti, +5

Endocrinology

Immune RegulationImmunologyPathologyOxidative StressInflammation +16

Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid

Tanihiro Yoshimoto, Miyamoto Yoshiyuki, Ochi Kenkichi, +1

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

OxysterolBiochemistryMedicineLipid PeroxidationReactive Oxygen Specie +5

Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells

Takahiro Kinoshita, Yoshitaka Takahashi, Toshiki Sakashita, +3

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Cancer ResearchCyclooxygenases 1PathologyCell ProliferationCell Growth +6

Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells

Masayuki Furukawa, Tanihiro Yoshimoto, Ochi Kenkichi, +1

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

OxysterolBiochemistryMedicineLipid PeroxidationArachidonate 5-Lipoxygenase +4

Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases

Juha Alanko, Yuko Kurahashi, Tanihiro Yoshimoto, +2

Biochemical Pharmacology

Medicinal ChemistryOriental MedicinesOxysterolInhibits Mammalian LipoxygenasesBiochemistry +10

Activation of matrix metalloproteinase‐2 in human breast cancer cells overexpressing cyclooxygenase‐1 or ‐2

Yoshitaka Takahashi, Futoshi Kawahara, Masakuni Noguchi, +6

FEBS Letters

Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase

Hiroshi Suzuki, Koji Kishimoto, Tanihiro Yoshimoto, +5

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

BiochemistryNatural SciencesIron-binding DomainHeme DegradationMolecular Biology +7