Al Charest

mTORC1 promotes survival through translational control of Mcl-1

John R. Mills, Yoshitaka Hippo, Françis Robert et al. · Proceedings of the National Academy of Sciences · 2008 · 281 citations · Full text

Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression

Alan T. Yeo, Shruti Rawal, Bethany Delcuze et al. · Nature Immunology · 2022 · 278 citations · Full text

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Helen Y. Zou, Qiuhua Li, Lars D. Engstrom et al. · Proceedings of the National Academy of Sciences · 2015 · 267 citations · Full text

Inhibitory Activity, Radiation Oncology, Fusion Kinases +14

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

Haihao Zhu, Jaime Acquaviva, Pranatartiharan Ramachandran et al. · Proceedings of the National Academy of Sciences · 2009 · 228 citations · Full text

Neuro-oncology, Oncogenic Egfr, Developmental Biology +13

ROS Fusion Tyrosine Kinase Activates a SH2 Domain–Containing Phosphatase-2/Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Signaling Axis to Form Glioblastoma in Mice

Al Charest, Erik Wilker, Margaret E. McLaughlin et al. · Cancer Research · 2006 · 165 citations · Full text