mTORC1 promotes survival through translational control of Mcl-1

John R. Mills, Yoshitaka Hippo, Françis Robert, +12

Proceedings of the National Academy of Sciences

Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression

Alan T. Yeo, Shruti Rawal, Bethany Delcuze, +10

Nature Immunology

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Helen Y. Zou, Qiuhua Li, Lars D. Engstrom, +20

Proceedings of the National Academy of Sciences

Inhibitory ActivityRadiation OncologyFusion KinasesNovel TherapyCrizotinib-resistant Ros1 Mutations +12

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

Haihao Zhu, Jaime Acquaviva, Pranatartiharan Ramachandran, +8

Proceedings of the National Academy of Sciences

Neuro-oncologyOncogenic EgfrDevelopmental BiologyGliomaMedicine +11

ROS Fusion Tyrosine Kinase Activates a SH2 Domain–Containing Phosphatase-2/Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Signaling Axis to Form Glioblastoma in Mice

Al Charest, Erik Wilker, Margaret E. McLaughlin, +9

Cancer Research

Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity

Franz Ricklefs, Marco Mineo, Arun K. Rooj, +7

Cancer Research

Implantable diagnostic device for cancer monitoring

Karen Daniel, Grace Kim, Christophoros C. Vassiliou, +6

Biosensors and Bioelectronics

EngineeringImplantable SensorImplantable Diagnostic DeviceBiomedical EngineeringImplantable Devices +2

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity

Aron Gyuris, José Navarrete-Perea, Ala Jo, +9

Cell Reports

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, +18

Nature Communications

ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis

Hyun Jung Jun, Jeremy Roy, Tegan Smith, +8

Endocrinology