Identification of the breast cancer susceptibility gene BRCA2

Richard Wooster, Graham R. Bignell, Jonathan Lancaster, +37

Nature

Breast OncologyCancer GenomicsBreast CancerCancer GeneticsMedicine +1

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

Nuala McCabe, Nicholas C. Turner, Christopher J. Lord, +9

Cancer Research

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

Neil Brockdorff, Alan Ashworth, Graham F. Kay, +5

Cell

GeneticsGene StructureGene RegulationGene CharacterizationMolecular Genetics +5

Identification of the familial cylindromatosis tumour-suppressor gene

Graham R. Bignell, William Warren, Sheila Seal, +38

Nature Genetics

Tumor BiologyGeneticsPathologyMolecular PathologyCancer Genetics +2

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

Frances Connor, David Bertwistle, P. Joseph Mee, +5

Nature Genetics

Knockout MouseChromatinGenome InstabilityDna DamageSomatic Variant +7

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

Nicholas C. Turner, Christopher J. Lord, Elizabeth Iorns, +6

The EMBO Journal

Parp InhibitorNatural SciencesGeneticsMolecular BiologyGene Regulation +6

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

David Komander, Christopher J. Lord, Hartmut Scheel, +4

Molecular Cell

Protein FoldingMedicineNatural SciencesMolecular BiologyLys63-linked Polyubiquitin +4

Structural basis for recruitment of BRCA2 by PALB2

Antony W. Oliver, Sally Swift, Christopher J. Lord, +2

EMBO Reports

Crystal StructureBiochemistryNatural SciencesMolecular BiologyStructure Elucidation +3

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

Christopher J. Lord, Sarah McDonald, Sally Swift, +2

DNA repair

Rna ProcessingGenome InstabilityNatural SciencesGeneticsRna Biology +8

A conserved family of genes related to the testis determining gene,<i>SRY</i>

Paul Denny, Sally Swift, Nigel J. Brand, +3

Nucleic Acids Research

Genetic TestingGeneticsGenomic MechanismMolecular BiologyGene Characterization +24