E5531, a Pure Endotoxin Antagonist of High Potency

William J. Christ, Osamu Asano, Andrea L. C. Robidoux, +19

Science

PharmacotherapyViable Escherichia ColiDrug ResistanceInflammationMolecular Pharmacology +14

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion

Elsa Wagner‐Rousset, Marie-Claire Janin-Bussat, Olivier Colas, +7

mAbs

Selenium-mediated glycosidations: A selective synthesis of β-2-deoxyglycosides

Michel Perez, Jean‐Marie Beau

Tetrahedron Letters

Bioorganic ChemistryBiochemistrySelenium DeficiencyNatural SciencesGlycobiology +2

Total Synthesis of the Proposed Structure of Rhodobacter sphaeroides Lipid A Resulting in the Synthesis of New Potent Lipopolysaccharide Antagonists

William J. Christ, Pamela D. McGuinness, Osamu Asano, +7

Journal of the American Chemical Society

Lipid AnalysisBioorganic ChemistryAltmetric Attention ScoreChemical BiologyPharmaceutical Chemistry +16

Serotonin Dimers:  Application of the Bivalent Ligand Approach to the Design of New Potent and Selective 5-HT_1B/1D Agonists

Serge Halazy, Michel Perez, Catherine Fourrier, +7

Journal of Medicinal Chemistry

Formula 4PharmacotherapyChemistryExperimental PharmacologySerotonin Dimers +17

A Simple One-Pot Preparation of N,N’-Unsymmetrical Ureas from N-Boc Protected Primary Anilines and Amines

Marie Lamothe, Michel Perez, Véronique Colovray-Gotteland, +1

Synlett

Combinatorial ChemistryEngineeringPrimary AminesSimple One-pot PreparationOrganic Chemistry +4

Solid-Phase Preparation of Hydantoins through a New Cyclization/Cleavage Step

Marie Lamothe, Marc Lannuzel, Michel Perez

Journal of Combinatorial Chemistry

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryHeterocyclicBiochemistry +11

Discovery of Novel Protease Activated Receptors 1 Antagonists with Potent Antithrombotic Activity in Vivo

Michel Perez, Marie Lamothe, Catherine Maraval, +13

Journal of Medicinal Chemistry

Antiplatelet DrugsImmunologyPharmacotherapyImmunotherapyThrombin-induced Platelet Aggregation +16

A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection

Robert E. Birdsall, Sean M. McCarthy, Marie Claire Janin-Bussat, +4

mAbs

Drug TargetEngineeringMass Spectral DetectionConjugation ProcessesMedicinal Chemistry +23

F 11356, a Novel 5-Hydroxytryptamine (5-HT) Derivative with Potent, Selective, and Unique High Intrinsic Activity at 5-HT1B/1D Receptors in Models Relevant to Migraine

Gareth W. John, Petrus J. Pauwels, Michel Perez, +14

Journal of Pharmacology and Experimental Therapeutics