Synthesis and Biochemical Evaluation of Δ²-Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors

Sabrina Castellano, Dirk Kuck, Monica Viviano, +7

Journal of Medicinal Chemistry

Drug TargetHuman Dnmt1Chemical BiologyPharmaceutical ChemistryChemical Derivative +22

Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase

Jakyung Yoo, José L. Medina‐Franco

Journal of Computer-Aided Molecular Design

Medicinal ChemistryDrug TargetBiochemistryStructure-based PharmacophoreNatural Sciences +10

Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

Jakyung Yoo, Sun Choi, José L. Medina‐Franco

PLoS ONE

Drug TargetEpigenetic ChangeDna MethylationMolecular BiologyEpigenetics +21

A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy

Woo‐Young Kim, Dong Chang, Bryan T. Hennessy, +11

Cancer Prevention Research

Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents

Fahad S. Aldawsari, Rodrigo Aguayo‐Ortiz, Kanishk Kapilashrami, +4

Journal of Enzyme Inhibition and Medicinal Chemistry

Natural PolyphenolMedicinal ChemistryMolecular Docking StudyChemoprevention StrategyOncogenic Agent +8

Biarylpyrazolyl Oxadiazole as Potent, Selective, Orally Bioavailable Cannabinoid-1 Receptor Antagonists for the Treatment of Obesity

Suk‐Ho Lee, Hee Jeong Seo, Sung-Han Lee, +12

Journal of Medicinal Chemistry

Synthesis and Biological Evaluation of 4(5)-(6-Alkylpyridin-2-yl)imidazoles as Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitors

Dae‐Kee Kim, Yoojeung Jang, Ho Soon Lee, +2

Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryLuciferase ReporterBioorganic ChemistryDiversity Oriented Synthesis +13

Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-<i>N</i>-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors

Dae-Kee Kim, Ju Young Lee, Jae-Sun Kim, +11

Journal of Medicinal Chemistry

Hdac InhibitorsPharmacotherapyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +16

Rational Design of an Indolebutanoic Acid Derivative as a Novel Aldose Reductase Inhibitor Based on Docking and 3D QSAR Studies of Phenethylamine Derivatives

Won Suck Sun, Yoon Sun Park, Jakyung Yoo, +4

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryIndolebutanoic Acid DerivativeChemical BiologyPharmaceutical Chemistry +14

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase

Hyoun Sook Kim, Ha Na Im, Doo Ri An, +17

Journal of Biological Chemistry

New FamilyProtein FunctionHigh MotilityProtein AssemblyBiochemistry +12