Genome-wide association study reveals genetic risk underlying Parkinson's disease

Javier Simón‐Sánchez, Claudia Schulte, José Brás, +42

Nature Genetics

Genome-wide Association StudyGeneticsGenetic EpidemiologyGenetic FactorNeurodegeneration +4

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

Simone Berkel, Christian R. Marshall, Jennifer Howe, +11

Nature Genetics

Neurodevelopmental DisordersSynaptic PlasticityMolecular NeuroscienceSyndromic AutismGenetic Disorder +12

Generation of pluripotent stem cells from adult human testis

Sabine Conrad, M. Renninger, Jörg Hennenlotter, +15

Nature

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyAdult Human TestisMedicine +8

Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease

Laurie Robak, Iris E. Jansen, Jeroen van Rooij, +134

Brain

GeneticsGenetic EpidemiologyVariant BurdenDisease Gene IdentificationGenome-wide Association Study +14

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

Suzanne Lesage, Valérie Drouet, Elisa Majounie, +212

The American Journal of Human Genetics

Cell AutophagyMitophagyMitochondrial FunctionGeneticsAutophagy +5

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

Alexandria Beilina, Iakov N. Rudenko, Alice Kaganovich, +160

Proceedings of the National Academy of Sciences

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

Fiona M. Menzies, Jeannette Huebener, Maurizio Renna, +2

Brain

Cell AutophagyMitophagyNeurodegenerative DiseasesMolecular NeuroscienceSignal Transduction +13

Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next‐generation sequencing

Dominik Buschmann, Benedikt Kirchner, Stefanie Hermann, +9

Journal of Extracellular Vesicles

Progression-Specific Genes Identified by Expression Profiling of Matched Ductal Carcinomas <i>In situ</i> and Invasive Breast Tumors, Combining Laser Capture Microdissection and Oligonucleotide Microarray Analysis

Christina S. Schuetz, Michael Bonin, Susan E. Clare, +8

Cancer Research

TREM2 is upregulated in amyloid plaque‐associated microglia in aged APP23 transgenic mice

Stefanie Frank, Guido J. Burbach, Michael Bonin, +4

Glia