Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

Ko‐Chung Lin, Humayun S. Ateeq, Sherry H. Hsiung, +14

Journal of Medicinal Chemistry

Inflammatory Lung DiseaseLung InflammationApoptosis InhibitionImmunologyPeptide Science +19

N-Terminally PEGylated Human Interferon-β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model

Darren P. Baker, Edward Yin-Shiang Lin, Ko‐Chung Lin, +13

Bioconjugate Chemistry

EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

James A. Sikorski, Michael J. Miller, Diane S. Braccolino, +11

Phosphorus, sulfur, and silicon and the related elements

Combinatorial ChemistryDiversity Oriented SynthesisBiosynthesisBiochemistryNatural Sciences +12

A Small-Molecule, Tight-binding Inhibitor of the Integrin α ₄ β ₁ Blocks Antigen-induced Airway Responses and Inflammation in Experimental Asthma in Sheep

William M. Abraham, Alan Gill, Ashfaq Ahmed, +8

American Journal of Respiratory and Critical Care Medicine

The intramolecular cycloaddition of azides with ω-chloroalkenes. A facile route to (±)-swainsonine and other indolizidine alkaloids

William H. Pearson, Ko‐Chung Lin

Tetrahedron Letters

Bioorganic ChemistryHeterocyclicBiochemistryFacile RouteNatural Sciences +6

A Small Molecule Very Late Antigen–4 Antagonist Can Inhibit Ovalbumin-induced Lung Inflammation

Gloria C. Koo, Kashmira Shah, G J Ding, +9

American Journal of Respiratory and Critical Care Medicine

InflammationAsthmaCytokineAnti-inflammatoryInflammatory Lung Disease +13

Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking

Ling Ling Chen, Roy R. Lobb, Julio H. Cuervo, +3

Biochemistry

Molecular BiologyChemical BiologyMolecular RecognitionLigand Binding SitesIntegrin α4β1 +15

Novel long‐acting ropeginterferon alfa‐2b: Pharmacokinetics, pharmacodynamics and safety in a phase I clinical trial

Yi‐Wen Huang, Albert Qin, Jane Fang, +5

British Journal of Clinical Pharmacology

3D QSAR (COMFA) of a series of potent and highly selective VLA-4 antagonists

Juswinder Singh, Herman van Vlijmen, Wen‐Cherng Lee, +10

Journal of Computer-Aided Molecular Design

EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics.

Michael J. Miller, Karen S. Anderson, Diane S. Braccolino, +8

Bioorganic & Medicinal Chemistry Letters

Biochemistry3-Phosphate GroupNatural SciencesEnzyme CatalysisProtein X-ray Crystallography +7