Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

Brenna C. Beckelman, Wenzhong Yang, Nicole P. Kasica, +5

Journal of Clinical Investigation

Eef2 KinaseSynaptic TransmissionSynaptic SignalingSocial SciencesProtein Synthesis +17

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

Helena R. Zimmermann, Wenzhong Yang, Nicole P. Kasica, +7

Journal of Clinical Investigation

Mammalian AmpkAmpkα IsoformsBrain-specific RepressionSynaptic SignalingSocial Sciences +16

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

Wenzhong Yang, Xueyan Zhou, Helena R. Zimmermann, +3

Neurobiology of Aging

Eif2α Kinase PerkSynaptic SignalingSocial SciencesNeuroinflammationAlzheimer's Disease +14

Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice

Saahj P. Gosrani, Hannah M. Jester, Xueyan Zhou, +2

Neurobiology of Aging

Cognitive ScienceMolecular NeuroscienceEef2 KinaseBrain FunctionCortical Remodeling +7

Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer’s disease

Wenzhong Yang, Xueyan Zhou, Alexey G. Ryazanov, +1

Neurobiology of Aging

Elongation Factor 2Neurodegenerative DiseasesSynaptic PlasticityAlzheimer's DiseaseMolecular Physiology +13

Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation

Wenzhong Yang, Xueyan Zhou, Helena R. Zimmermann, +1

Molecular Psychiatry

Hippocampal LtpCognitive ScienceMolecular NeuroscienceSynaptic SignalingNeurophysiology +11

Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity

Wenzhong Yang, Xueyan Zhou, Tao Ma

Frontiers in Aging Neuroscience

AgingSynaptic TransmissionStructural PlasticityMemory DeclineTerminal Oligopyrimidine +21

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

Megha Jhanji, C.N.R. Rao, Jacob C. Massey, +7

Nature Communications

Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model mice

Nicole P. Kasica, Xueyan Zhou, Qian Yang, +11

Journal of Neurochemistry

Impaired Mrna TranslationSynaptic TransmissionAlzheimer ’Synaptic SignalingSocial Sciences +17

Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease

Brenna C. Beckelman, Xueyan Zhou, C. Dirk Keene, +1

Neurodegenerative Diseases