Samantha Perino

Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Kerry A. Whalen, Brian H. White, James M. Quinn et al. · Molecular Cancer Therapeutics · 2019 · 73 citations · Full text

Medicine, Oncology, Pharmaceutics +17

Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo

Brian H. White, Kerry A. Whalen, Kristina Kriksciukaite et al. · Journal of Medicinal Chemistry · 2019 · 53 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Total Synthesis of 6-Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line

Kenzo Arai, Silvia Buonamici, Betty Chan et al. · Organic Letters · 2014 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors

Samantha Perino, Benoît Moreau, Jessica Freda et al. · Molecular Cancer Therapeutics · 2020 · 11 citations · Full text

Medicine, Oncology, Pharmacology +15

Abstract CT186: Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM

Sagar Lonial, Shambavi Richard, Jeffrey Matous et al. · Cancer Research · 2022 · 11 citations

Medicine, Oncology, Pharmacology +13