Steven Grant

Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.

Yun Dai, Chendi Yu, Vibha Singh et al. · PubMed · 2001 · 161 citations

Mitophagy, Chemoprevention Strategy, Mitochondrial Dysfunction +16

Coordinate Regulation of Stress- and Mitogen-Activated Protein Kinases in the Apoptotic Actions of Ceramide and Sphingosine

W. David Jarvis, Frank A. Fornari, Kelly L. Auer et al. · Molecular Pharmacology · 1997 · 152 citations

Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

Sujit K. Bhutia, Rupesh Dash, Swadesh K. Das et al. · Cancer Research · 2010 · 120 citations

PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in <i>mda</i> -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Adly Yacoub, Hossein A. Hamed, Jeremy C. Allegood et al. · Cancer Research · 2010 · 107 citations · Full text

<i>mda-7</i>(IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling

Adly Yacoub, Clint Mitchell, Irina V. Lebedeva et al. · Cancer Biology & Therapy · 2003 · 95 citations