Sabrina Köcher

Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma

Wael Mansour, Natalia Bogdanova, Ulla Kasten-Pisula et al. · Radiotherapy and Oncology · 2012 · 68 citations

Clinical Hypersensitivity, Mir-421 Downregulates Atm, Aberrant Overexpression +10

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

Sabrina Köcher, Thorsten Rieckmann, Gabor Rohaly et al. · Nucleic Acids Research · 2012 · 47 citations · Full text

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining

Ulrike Schötz, Viola Balzer, Friedrich-Wilhelm Brandt et al. · Cancers · 2020 · 39 citations · Full text

Double-strand Break, Molecular Biology, Dsb Repair +18

Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice

Ali Bakr, Sabrina Köcher, Jennifer Volquardsen et al. · Radiotherapy and Oncology · 2015 · 27 citations

Chromatin, Genome Instability, Dna Damage +8

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

Ali Bakr, Sabrina Köcher, Jennifer Volquardsen et al. · Oncotarget · 2016 · 27 citations · Full text