W.J. Gui

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Haipeng Sun, Kristine C. Olson, Chen Gao et al. · Circulation · 2016 · 536 citations · Full text

Life Sciences, Biochemistry, Cardiology +17

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

Meiyi Zhou, Jing Shao, Cheng‐Yang Wu et al. · Diabetes · 2019 · 314 citations · Full text

Medicine, Endocrinology, Molecular Genetics +15

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

Shih-Chia Tso, W.J. Gui, Cheng‐Yang Wu et al. · Journal of Biological Chemistry · 2014 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Shih-Chia Tso, Xiangbing Qi, W.J. Gui et al. · Journal of Biological Chemistry · 2013 · 108 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +12

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

Shih-Chia Tso, Xiangbing Qi, W.J. Gui et al. · Proceedings of the National Academy of Sciences · 2013 · 72 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17