Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial

Salah‐Eddin Al‐Batran, Nils Homann, Claudia Pauligk, +53

The Lancet

Surgical OncologyEsophageal CancerGastrointestinal OncologyMedicineVersus Fluorouracil +7

Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood–brain barrier

Hans‐Joachim Stemmler, Manfred Schmitt, Amina Willems, +3

Anti-Cancer Drugs

Median Trastuzumab LevelBreast OncologyBlood–brain BarrierMedicineCerebrospinal Fluid +13

Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptidesin vivo: Implications for tumor vaccines with melanoma-associated antigens

E. Jaeger, Helga Bernhard, Pedro Romero, +6

International Journal of Cancer

Positron Emission Tomography–Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial

Ulrich Dührsen, Stefan Müller, Bernd Hertenstein, +41

Journal of Clinical Oncology

Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer

Michael Knabel, Tobias Franz, Matthias Schiemann, +6

Nature Medicine

HistocompatibilityT-regulatory CellImmunologyAntigen ProcessingAutoimmunity +8

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

Martin Sebastian, Andreas Schröder, Birgit Scheel, +23

Cancer Immunology Immunotherapy

Cancer ImmunosurveillancePhase I/iia StudyMedicineImmunologyCancer Genomics +6

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.

Helga Bernhard, Mary L. Disis, Shelly Heimfeld, +3

PubMed

Cd34 MoleculeImmunologyBlood CellPathologyPeripheral Blood +20

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines

Ingo Drexler, Caroline Staib, Wolfgang Kastenmüller, +8

Proceedings of the National Academy of Sciences

VaccinationVaccine DevelopmentVaccine ResearchVaccine TargetImmunology +13

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer

Helga Bernhard, Julia Neudorfer, Kerstin Gebhard, +7

Cancer Immunology Immunotherapy

Cell TherapyBreast OncologyHer2-overexpressing Breast CancerImmunologyBreast Cancer +7

Antihuman epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab enhances cytolytic activity of class I-restricted HER2-specific T lymphocytes against HER2-overexpressing tumor cells.

Christian Meyer zum Büschenfelde, Christine Hermann, Burkhard Schmidt, +2

PubMed

Tumor ImmunologyMonoclonal Antibody TrastuzumabHer2-overexpressing Breast CancerCancer ImmunosurveillanceHer2 Peptides +11