Treviño Isaac

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

Brandon Probst, Treviño Isaac, McCauley Lyndsey et al. · PLoS ONE · 2015 · 100 citations · Full text

Medicine, Oncology, Pharmacology +17

Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405

Brandon Probst, McCauley Lyndsey, Treviño Isaac et al. · PLoS ONE · 2015 · 83 citations · Full text

Medicine, Oncology, Pharmacology +17

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Carlos Huerta, Xin Jiang, Treviño Isaac et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 2016 · 67 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents

Suqing Zheng, Y. R. Santosh Laxmi, Emilie David et al. · Journal of Medicinal Chemistry · 2012 · 61 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells

Yanfeng Ding, Rhesa D. Stidham, Ron Bumeister et al. · Kidney International · 2012 · 51 citations · Full text

Medicine, Nephrology, Pharmacology +10