Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong‐Hee Cho, Sang Gyu Lee, +15

Nature Chemical Biology

Protein FunctionSignal TransductionSignaling PathwayMolecular RegulationSmall-molecule Binding +10

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

Pu-Hyeon Cha, Jeongha Hwang, Dong-Kyu Kwak, +3

British Journal of Cancer

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

Sehee Choi, Hyun-Yi Kim, Pu-Hyeon Cha, +8

Life Science Alliance

Hovenia dulcis Thunb Extract and Its Ingredient Methyl Vanillate Activate Wnt/β-Catenin Pathway and Increase Bone Mass in Growing or Ovariectomized Mice

Pu-Hyeon Cha, Wookjin Shin, Muhammad Asif Zahoor, +3

PLoS ONE

Bone DiseaseMolecular PharmacologyAvailable Anti-osteoporosis DrugMetabolic Bone DiseaseMedicine +11

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Won-Ji Ryu, Jeong Dong Lee, Jong‐Chan Park, +6

Experimental & Molecular Medicine

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

Yong‐Hee Cho, Pu-Hyeon Cha, Saluja Kaduwal, +10

Oncotarget

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Sang Gyu Lee, Yong‐Hee Cho, Pu-Hyeon Cha, +9

Experimental & Molecular Medicine

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Jieun Park, Yong‐Hee Cho, Wook-Jin Shin, +10

Scientific Reports

Indirubin-3′-Oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice Via Activation of the Wnt/β-Catenin Signaling

Muhammad Asif Zahoor, Pu-Hyeon Cha, Do Sik Min, +1

Journal of Bone and Mineral Research

Indirubin-3′-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

Muhammad Asif Zahoor, Pu-Hyeon Cha, Kang‐Yell Choi

Bone

ObesityBone LossHealth SciencesPhysiologyOsteoporosis +9