Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

Toshiaki Matsui, Tsuneyuki Sugiura, Hisao Nakai, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmacological StudyBiochemistryMedicine +12

X-Ray structure of the α-cyclodextrin–ferrocene (2 : 1) inclusion compound

Yoshihiko Odagaki, Ken Hirotsu, Taiichi Higuchi, +2

Journal of the Chemical Society Perkin Transactions 1

X-ray CrystallographyInorganic ChemistryMaterials ScienceCrystal StructureApproximate D5d Symmetry +10

Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

Kazuyuki Ohmoto, Tetsuya Yamamoto, Motohiro Okuma, +13

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryImmunologyPharmacotherapyPharmaceutical Chemistry +15

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

Kazuyuki Ohmoto, Tetsuya Yamamoto, Toshihide Horiuchi, +12

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryAntimicrobial Drug DiscoveryHuman Neutrophil ElastasePharmaceutical Science +13

Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity

Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineHuman RetrovirusImmunologyStrong Anti-hiv Activity +8

Diastereoselective Synthesis of New <i>ψ</i>[(<i>E</i>)-CHCMe]- and <i>ψ</i>[(<i>Z</i>)-CHCMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics

Shinya Oishi, Takae Kamano, Ayumu Niida, +6

The Journal of Organic Chemistry

Clarification of Mechanism of Human Sputum Elastase Inhibition by a New Inhibitor, ONO-5046, Using Electrospray Ionization Mass Spectrometry

Yoshisuke Nakayama, Yoshihiko Odagaki, Setsuko Fujita, +4

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineNatural SciencesBioanalysisMass Spectrometry +9

New Orally Active Serine Protease Inhibitors

Kazuhiko Senokuchi, Hisao Nakai, Yoshisuke Nakayama, +10

Journal of Medicinal Chemistry

Preclinical TherapeuticsAltmetric Attention ScorePharmacotherapyPharmaceutical ChemistryPre-clinical Pharmacology +18

X-ray structure of a sterically protected 1-aza-3-phospha-allene

Masaaki Yoshifuji, Takashi Niitsu, Kozo Toyota, +5

Polyhedron

X-ray CrystallographyX-ray SpectroscopyEngineeringX-ray StructureNatural Sciences +3

Regio- and Stereoselective Synthesis of (<i>E</i>)-Alkene <i>trans</i>-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated <i>A</i><i>nti</i>-S_N2‘ Reactions

Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, +5

The Journal of Organic Chemistry