Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

Toshiaki Matsui, Tsuneyuki Sugiura, Hisao Nakai, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmacological StudyBiochemistryMedicine +12

4-alkoxycarbonyloxazoles as β-hydroxy-α-amino acid synthons: efficient stereoselective syntheses of 3-amino-2,3,6-trideoxyhexoses and a hydroxy amino acid moiety of Al-77-B

Yasumasa Hamada, Akiyoshi Kawai, Toshiaki Matsui, +2

Tetrahedron

Enantioselective SynthesisBiochemistryNatural Sciencesβ-Hydroxy-α-amino Acid SynthonsOrganic Chemistry +4

Total synthesis of (±)-sanadaol

Hiroto Nagaoka, Kaoru Kobayashi, Toshiaki Matsui, +1

Tetrahedron Letters

Synthetic ChemistryChemistryTotal Synthesis

Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group

Atsushi Naganawa, Toshiaki Matsui, Masaki Ima, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +9

Highly potent inhibitors of tnf-α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Toshiaki Matsui, Takashi Kondo, Yoshitaka Nishita, +14

Bioorganic & Medicinal Chemistry

Active DiastereoisomerMedicinal ChemistryBiochemistryNatural SciencesMedicine +8

6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists

Tetsuji Saito, Tetsuo Obitsu, Takashi Kondo, +10

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineReceptor AntagonistsMechanism Of Action +4

Highly potent inhibitors of TNF-α production. Part 2: identification of drug candidates

Toshiaki Matsui, Takashi Kondo, Yoshitaka Nishita, +12

Bioorganic & Medicinal Chemistry Letters

Drug CandidatesMedicineImmunologyHighly Potent InhibitorsPharmacotherapy +6

Highly Potent Inhibitors of TNF-α Production. Part 1: Discovery of Chemical Leads

Toshiaki Matsui, Takashi Kondo, Yoshitaka Nishita, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPart 1BiochemistryMedicineNatural Sciences +8

Highly potent inhibitors of TNF-α production. Part I

Toshiaki Matsui, Takashi Kondo, Yoshitaka Nishita, +13

Bioorganic & Medicinal Chemistry

MedicineImmunologyHighly Potent InhibitorsAnti-cancer AgentPharmacology +2

Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists

Atsushi Naganawa, Toshiaki Matsui, Masaki Ima, +9

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryFunctional SelectivityNatural SciencesMedicine +9